By Dr. Adam Schneeweiss, Dr. Marija Weiss (auth.)
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Extra resources for Advances in Nitrate Therapy
They compared veins from patients not treated with organic nitrates prior to surgery to those of patients pretreated for more than 2 weeks with ISDN, 40, 80 and 160 mg daily. Contraction of the vessel strips was induced by sodium chloride, and ISDN was then added to the solution. In the venous vessel strips of all four groups comparable concentration-dependent relaxation was measured, irrespective of ISDN pretreatment. In conclusion, chronic pretreatment of patients with ISDN, even at high doses, does not impair relaxation of isolated circular venous vessel strips.
Rezakovic and Rutishauser reported at the World Congress of Cardiology (Moscow 1982) on different hemodynamic effects of nitroglycerin and ISDN in acute myocardial infarction. An invasive hemodynamic study in 30 patients revealed that nitroglycerin has mainly a peripheral venodilatory effect, and that it also reduces pulmonary vascular resistance. ISDN produces these effects and, in addition also reduces the systemic vascular resistance. ) published over 10 years ago a series of reports on the hemodynamic effects of various nitrate formulations in acute myocardial infarction.
28 Nitrates Compared and Combined with Other Antianginal Drugs In a recent review on comparisons and combinations in antianginal therapy Julian  stated that nitrates, beta-blockers and calcium antagonists are about equally effective in their ability to prevent exercise-induced angina. " The optimal dose of nifedipine shows interpatient variability, and accurate determination of the optimal dose might be crucial with this drug. Increasing the dose of nifedipine might decrease rather than increase the antianginal effect .
Advances in Nitrate Therapy by Dr. Adam Schneeweiss, Dr. Marija Weiss (auth.)